Breast, Endometrial, Colon and Lung Cancer Related to High Estrogen
   CHI HEALTH LETTER                                                                                                                September 2016
IN THIS ISSUE


Cancer in the immediate family

Second degree relatives with cancer increases your risk

Lynch Syndrome

Lung Cancer and Estrogen

Myomin for Estrogen-Related Cancers


Estrogen Quotient

Aromatase Inhibitors better than Tamoxifen

When to Use Myomin 


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Do you have Cancer in your Immediate Family? 
 
In the last newsletter, we discussed how to detect estrogen dominance (cherry angiomas, red dots on the tongue, etc.) as well as its related health risks. Estrogen has been known to increase the risk and worsen the prognosis of breast, ovarian, endometrial, uterine, thyroid and prostate cancer. It has also been linked to melanoma and lymphoma. But did you know that colon and lung cancer are related to estrogen as well?

Here we will talk about estrogen-mediated cancers specifically. In the next newsletter, we will discuss genetic markers of cancer (e.g., growth factor receptors, etc.) and how Angiostop can address them.

If you have a personal history of having one of these cancers already increases your risk of developing the same type of cancer. But having one of cancers above in the immediate family increases your chance of developing any of these cancers. For example, if a female sibling has breast or endometrial cancer, then the male sibling has a high chance of colon cancer. The following cases illustrate how cancer in the immediate family increases your risk:

T.L. from CA found blood in his stool back in June 2011, which is a warning sign of a colon problem. His mother had died of colon cancer so he already has a strong risk for it. He was also a smoker, increasing his risk for lung cancer. About a year later, he was indeed diagnosed with lung cancer. In 2013, he was diagnosed with colon cancer.

M. Tobias, DC from MI, relates that his father had colon cancer. He himself, at age 45, already had a frenula cyst (sign of colon problem) and high estrogen level. So he immediately took action to prevent colon cancer because of his increased risk. Later in this newsletter, we will be discussing the markers and symptoms related to specific types of cancers.

L. C., 59 y/o/f from CA, relates that one of her brothers was diagnosed with pancreatic cancer, the other brother with melanoma and her sister with breast cancer and then later with thyroid cancer. She became worried because she herself needs to undergo a thyroid ultrasound and possible further testing. She does have a very high risk for cancer with 3 siblings developing cancer and two of them with melanoma and breast cancer which are estrogen-responsive.
Having Two Second Degree Relatives with Cancer Increases Risk
 
Even if the relationship is not as close, there is still a risk. If you have two 2nd degree blood relatives with breast, endometrial, colon or lung cancer, your risk for developing one of these cancers also increases. So this means that if you have a grandparent or a cousin or an uncle who had one of these cancers, you should be concerned already, especially if you are already showing markers of estrogen dominance, such as cherry angiomas on the torso or red dots on the tongue. You can also look for markers and symptoms that pinpoint a risk for breast, endometrial, colon or lung cancer (Table 1). If you find that you do have these markers and symptoms, first you can check your estradiol level. You can also check cancer markers that are specific to a cancer type. Table 1 lists a guide to the typical cancer markers used to screen for various types of cancers. This table is a useful reference to determine your cancer risk.






















For example, in the case of Dr. Tobias above, he had a cyst on his frenula which is a sign of a colon problem. He checked his estradiol level and it was indeed high. So with his confirmed high estrogen level, he was right in being concerned about his high risk and so he immediately started to prevent colon cancer.

Below we see an example of how cancer not just in the immediate family but within two degrees increases risk and how physical markers already confirm this risk as well as the link to estrogen dominance.

J. Seibert, ND from OR, has a 51 y/o/f patient whose grandparents both died of colon cancer and whose father died of lung cancer. This already puts her at risk for developing colon and lung cancer as well as female organ cancers. She became even more concerned because she has many cherry angiomas in the abdomen, indicating estrogen dominance. Her estrogen quotient (E3/ E1 + E2) is also not ideal. Her estrone (E1) is 50, estradiol (E2) is < 15 and estriol (E3) is < 0.1, so her estrogen quotient is much less than 1, indicating a risk for breast cancer. The estrogen quotient will be discussed in more detail in a later section.
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 Lynch Syndrome: Colorectal Cancer Link to Other Cancer May Not Only Be Genetic 
 
Lynch syndrome is a genetic condition that increases the risk of colorectal cancer, usually seen at a younger age and also in multiple members of the family. It also increases the risk of endometrial, gastric, ovarian, intestinal, pancreatic, bladder, kidney, brain, breast and prostate cancer. While it is an inherited syndrome the cause may not all be genetic. In fact, the American Cancer Society recommends that women who have a strong family history of colon cancer (even with negative genetic testing) get annual endometrial biopsies starting at age 35. Having no children, infertility, late menopause, obesity and diabetes are all risk factors contributing to the development of endometrial cancer. High estrogen also plays a major part in endometrial cancer. And this could well be the common denominator among these types of cancer.
Lung Cancer Linked to Estrogen
 
Estrogen has been found to play a role in lung cancer. Studies show that women develop lung cancer 3 times more frequently than men (References: Medical Hypothesis. 2011; 76(3):328-31; Steroids. 2011 Mar 30 epub; Cancer. 2011; 117(6):1288-95 ) . The underlying reason for this is estrogen. Of course, having a family history is also another strong risk factor, such as in this case.

K. P., 57 y/o/f from CA, had lung cancer removed in 2007. Her brother and sister also had lung cancer, underwent chemotherapy, radiation and used Tarceva. Both died within 2-3 years. In 2012, she found 4 lung nodules and was given isoflavones from soy. Within 6 months, it became Stage IV non-small cell lung cancer. In Jul 2013, she started taking Angiostop, Revivin and Myomin. In Nov 2013, she added Tarceva. By Feb 2014, her lung tumors decreased in size and so she reduced Angiostop. In May 8, 2016, she was given enzymes containing isoflavones and then stopped taking Angiostop. Within 7 weeks, her cancer had spread to the brain. Now the doctor stopped Tarceva and gave her chemotherapy.

In this case, first the patient has a strong family history of lung cancer, with both her brother and sister also diagnosed with the disease. Notice though that in K.P.’s case she was given estrogenic compounds (isoflavones) twice and in both instances her lung nodules developed into cancer and later on it spread to the brain. Lung cancer is estrogen-responsive so lung cancer patients should avoid soy isoflavones and other estrogenic substances.

Another case illustrates the link between and prostate and breast cancer, both estrogen-responsive conditions.

D. F. is a 51 y/o/m from FL who started the HCG diet at age 47 in 2013. His testosterone was 350 and PSA was 3. Ideally PSA should be under 1. His mother had died of breast cancer at age 51. After about a year, his testosterone shot up to 1400 and his PSA increased to 5.9. He was then diagnosed with prostate cancer. A biopsy showed 3 of 12 cores were cancerous with a Gleason score of 6 to 7. At that point, he was overweight at 300 lbs, had low energy and was depressed. In Mar/Apr 2014, he started taking Angiostop, Myomin, Revivin, Asparagus Extract, and Prosta Chi. By Jan 2015, his PSA has reduced to 2.9 and he also lost 78 lbs (Table 2).

Myomin and Angiostop for Estrogen-Related Cancers
 
Being aware of your risks as well as family history can be useful in making sure that you take the right action to correct the issue. For example, in D.F.’s case above, he immediately stopped the testosterone injections, which was promoting his estrogen dominance through hyperaromatization of testosterone to estrogen. He also took supplements to reduce his PSA. Just like what D.F. did, supplements like Myomin and Angiostop, at least, are recommended to not only reduce risk but to actually suppress cancer, especially estrogen-dominant cancers.

MYOMIN for Correcting Estrogen Dominance

For any cancers that respond to estrogen, Myomin is highly recommended. Here we mentioned breast, prostate, endometrial, uterine, colon and lung cancer as estrogen-dominant. In the previous issue of the newsletter, we discussed that estrogen is related to melanoma and lymphoma as well. So anytime you have any of these cancers, Myomin should be added.

Myomin is a natural aromatase reducer that blocks the hyperaromatization of androgens to estrogen, effectively reducing estrone (E1) and estradiol (E2) while allowing the production of the “good” estrogen, estriol (E3).

Estrogen Quotient> 1 Linked to Lower Cancer Risk

It was found that women were more likely to be long-term breast cancer survivors if they had more E3 than E1 and E2 combined. We see this more clearly in what is called the estrogen quotient or EQ.

EQ= E3/ (E1 + E2)

According to Professor Henry Lemon, an EQ> 1 is associated with reduced risk for estrogen-related cancers (Sources: Townsend Letter. Aug/Sep 2010: 54-56; Townsend Letter. Jan 2010: 56-58).

Those on hormone replacement therapy (HRT), even bioidentical HRT or BHRT, should take Myomin. Studies show that HRT users (e.g., Prempro, Premarin, DHEA, Progesterone, testosterone, estradiol, etc. and even birth control pills) have a 63% higher incidence of breast, ovarian and endometrial cancer compared to non users. Dr. Jonathan Wright, MD, the pioneer of BHRT, recommends taking Myomin to correct estrogen dominance as this increases the risk of hormone-related cancer (Sources: Lancet. 2007 Apr 10; JAMA. Nov 2009; Townsend Letter. Jan 2010: 56-58).
Aromatase Inhibitors better than Estrogen Blockers (Tamoxifen) for Breast Cancer
 
Conventionally, an estrogen blocker like tamoxifen is typically recommended for breast cancer. However, studies show that aromatase inhibitors are better than tamoxifen in minimizing recurrence, increasing survival and reducing metastases and have fewer side effects (Figure 1). (Sources: J Clinical Oncology. 2008; 26(12): 1948-56; Lancet Oncology. 2008; 9(1):45-53).



Tamoxifen only antagonizes estrogen receptors and does not actually reduce estrogen. So estrogen can still potentially fuel cancer growth, like in this case.

P. Schwarz, ND from CA, has a 53 y/o/f who had bilateral mastectomy in December 2011 due to Stage 2 ER+ breast cancer. She took Tamoxifen after surgery. In Feb 2015, a PET scan found lesions and nodules in her liver and lungs. Tamoxifen is really not ideal for this patient because, first, it is better suited for younger women and, second, it only blocks estrogen and does not reduce it. We see this reflected in high levels of E1 and E2 while her E3 is low. Her EQ is definitely too low (Table 3), suggesting that she is still at risk for estrogen-related cancer. The lesions and nodules in her liver and lungs may already be signs of that.

Estrogen blockers like Tamoxifen also may have other unwanted effects.

For example, L. Usher, ND from GA, has a 68 y/o/f patient who had 1 dose of radiation in May 2016 for breast cancer and was prescribed Tamoxifen for 5 years. Only after 2 weeks of taking tamoxifen, she already gained 6 lbs. Again, tamoxifen was not suited for this patient who was postmenopausal. It only blocked estrogen but she still had estrogen in her body which was causing the weight gain.

Myomin better than aromatase inhibitors

While aromatase inhibitors (AIs) are better than estrogen blockers, Myomin has a distinct advantage over AIs. Because it does not inhibit aromatase but rather reduce it, the effect is even better. Furthermore, AIs block all three types of estrogen, E1, E2, and E3, causing many side effects, including bone loss.

Even after breast cancer surgery, Myomin may still be needed because estradiol can still increase, such as in this case.

M. Guevara, MD from CA, has a 49 y/o/f patient with Stage 3 ER+ breast cancer. She had a bilateral mastectomy in October 2013. Typically estradiol reduces after breast cancer surgery. But despite the surgery, her estradiol level was still high at 278 in December 2013. If she does not reduce her estradiol, her cancer can metastasize or recur. So she started taking Myomin in February 2014. After 3-4 months, her estradiol reduced to normal (Table 4).

Take Myomin if you have any Estrogen-Dominant Condition or if you are on BHRT to Avoid Estrogen-Related Cancer
 
When you already have a history of cysts, fibroids, endometriosis, dense breasts, prostate or testicular problems and similar conditions, you need to take Myomin to correct estrogen dominance. You know that these are estrogen-responsive conditions so you must keep your estrogen at an ideal level. And most importantly, do not take anything that can fuel and worsen the condition, like BHRT. But if you have to be on HRT or any hormones, you must add Myomin to counteract their unwanted effects. Below is a guide to when Myomin is recommended, especially in cases where BHRT is involved (Table 5).


The case below is an example of what might occur if Myomin is not added to progesterone.

R.B., 59 y/o/f from IL, has been taking progesterone for hormonal imbalance but did not take Myomin. About a year later after she started progesterone, her hormones are still imbalanced. And her EQ is under 1, indicating an increased risk for cancer (Table 6).

In the next case, progesterone was given to a patient with fibroids and bleeding worsened. Myomin should always be added anytime progesterone is used.

About 7 years ago, a 43 y/o/f patient had 21 fibroids that were removed. About 3-4 years after that, she again developed 4 fibroids. At this time, she took Myomin for about 4 years and was doing well but she had mild hot flashes. Myomin may cause hot flashes in about 50% of cases but the dose can be adjusted. This patient, however, did not adjust the dose and recently went to an acupuncturist who asked her to stop taking Myomin and recommended progesterone. Within 2 months, her hot flashes and mood swings did get better, but her periods were longer with some spotting in between. After 4 months on the progesterone, she stopped it because of the increased bleeding. Now she is back on the Myomin.
 SUMMARY

Estrogen is an underlying factor in many types of cancer. We are familiar with breast, ovarian, prostate, endometrial and uterine cancers as estrogen-related. Lung and colon cancer are linked to estrogen as well. That is why if you have a family history of any of this cancer, even second degree relatives, you should be aware of your risk.

You can check for cherry angiomas to see if you are estrogen dominant. You can also check your E2 level to verify it. There are also physical markers or symptoms specific to certain cancer types as well as cancer markers that can be tested (see Table 1).

But if you already have a family history of these estrogen-related cancers, especially if you are showing signs of estrogen dominance, you should start taking Myomin to correct it and lower your risk. Also if you already have a history of estrogen-dominant conditions like fibroids, cysts, prostate issues, etc., or you are on HRT or BHRT, you know that your risk is even higher, so taking Myomin is important.

Besides Myomin, Angiostop is also recommended for all types of cancers to address the genetic factors. It suppresses cancer effectively through multiple pathways. Get more details about Angiostop in our next issue.
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